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Noyan Gokce, MD, professor of medication at Boston College Chobanian & Avedisian College of Drugs, has been awarded a $453,750 Nationwide Institutes of Well being (NIH) R-21 grant for his analysis research “Affect of Per/Polyfluoroalkyl (PFAS) pollution on vascular illness mechanisms.” This work can be carried out in collaboration with co-investigator Jennifer Schlezinger, PhD from the Boston College College of Public Well being.
Per- and polyfluoroalkyl substances (PFAS) are artifical chemical compounds which might be extensively utilized in industrial and shopper merchandise reminiscent of stain- and water-repellent materials, meals contact supplies, polishes, waxes, paints and foams. PFAS are omnipresent within the surroundings together with our meals and consuming provides and could be absorbed by people.
Gokce’s analysis undertaking will deal with the rising proof that PFAS exposures are related to damaging well being outcomes and will play a job within the pathogenesis of cardiovascular illnesses. “Our preliminary information exhibits that PFAS disrupt key physiological capabilities of human blood vessels by impairing arteriolar vasomotor operate and angiogenesis,” says Gokce, who is also Director of Echocardiography at Boston Medical Middle (BMC).
He’ll look for the primary time to characterize the causal pathophysiological actions of various lessons of PFAS toxicants upon the human vascular system. “The general undertaking tackles an unmet medical want for modern analysis as outlined by the not too long ago established PFAS Commitments to Motion Strategic Roadmap (2021-2024) by the EPA, for understanding how PFAS pollution can play causal roles in mediating human illness,” he explains.
Gokce is a fellow of the American Faculty of Cardiology (FACC), American Society of Echocardiography (FASE) and a member of the American Society for Scientific Investigation (ASCI). He’s board licensed in cardiovascular illnesses and grownup echocardiography. He’s recipient of the Excellence in Scientific Educating award in 2006, 2011, 2017 and 2019 within the cardiovascular division. He’s the recipient of the Collaborator of the 12 months award in medical/translational sciences at BMC, in addition to the Division of Drugs’s first prize in medical analysis.
His laboratory has been NIH funded for 20 consecutive years and he’s at the moment the principal investigator on a number of NIH R01 grants that research the relationships between dysfunctional adipose tissue in human fats shops and cardiometabolic dysfunction.
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